Early Letters Research Articles

The Reinforced Treat-and-Extend Protocol for Exudative Age-Related Macular Degeneration: Retrospective Assessment of 24-Month Real-World Outcomes in France.

The aim of this work is to evaluate the real-world outcomes of the reinforced treat-and-extend (RTE) protocol for the treatment of exudative age-related macular degeneration with intravitreal injections of aflibercept or ranibizumab (anti-vascular endothelial growth factor therapies). This was a retrospective review of patients from two tertiary ophthalmology centers in France initiating the RTE protocol between February 2018 and June 2021. The primary outcome was change in best-corrected visual acuity (BCVA) after 24months. Secondary outcomes were change in central retinal thickness (CRT), recurrence, and management-related factors (injection interval, number of injections/consultations). Outcomes were additionally evaluated after protocol changes (strict versus modified RTE protocol groups). Sixty-eight patients (72 eyes) were included (68% females; mean age 82.2 ± 7.8years). After 24months, mean BCVA significantly improved (65.22 ± 14 vs. 71.96 ± 13 Early Treatment Diabetic Retinopathy Study letters; p < 0.001) and CRT significantly decreased (388.6 ± 104 vs. 278.8 ± 51μM; p < 0.001) with 21% of eyes showing signs of exudation. Over the 24months, a mean total of 14.9 ± 4.0 injections and 8.6 ± 1.4 consultations were performed. Mean 24-month injection interval was 7.9 ± 2.3weeks. Initial and 24-month ophthalmic outcomes for eyes in the strict (47%) versus modified (53%) groups were not significantly different, but mean time interval to first recurrence of disease activity was significantly shorter for the modified group (7.3 ± 2.4 vs. 9.9 ± 2.5weeks; p < 0.001). Patients in the strict RTE group received significantly less injections (13.9 ± 3.6 vs. 16.5 ± 3.9; p = 0.006) and mean 24-month injection interval was significantly longer (9.5 ± 2.7 vs. 6.5 ± 2.1weeks; p < 0.001). Consultation number was similar (8.5 ± 1.9 vs. 8.8 ± 1.6; p = 0.93). Treatment with aflibercept versus ranibizumab did not influence ophthalmic or management outcomes. The RTE protocol, even when modified, reduced consultations but improved ophthalmic outcomes. The RTE protocol could reduce hospital visits and overall burden while also encouraging better patient compliance. Video Abstract available for this article. Vincent Soler and François-Philippe Roubelat summarize the Reinforced Treat-and-Extend Protocol and main results (MP4 225022 KB).

The Natural History of Retinal Sensitivity Loss in Diabetic Macular Ischemia over One Year Evaluated by Microperimetry

Background/Objectives: This one-year prospective observational study, conducted at two centers, aimed to report the natural history of retinal sensitivity (RS) loss in diabetic macular ischemia (DMI). Methods: Patients with stable-treated proliferative diabetic retinopathy (PDR) were recruited if there was evidence of DMI on optical coherence tomography angiography, defined as a foveal avascular zone ≥ 0.5 mm2 or parafoveal capillary dropout ≥ 1 quadrant. The minimal visual acuity required for performing microperimetry (MP) was ≥54 Early Treatment Diabetic Retinopathy Study letters (Snellen equivalent 20/80). The overall RS (oRS) and pointwise sensitivity (PWS) within the 3 × 3 mm macula were assessed at baseline and twelve months. A value &lt;25 decibels (dB) was defined as impaired RS, and a decrease of 2 and 7 dB was regarded as mild and severe loss, respectively. Results: A total of 88 patients (97 eyes) were included. No statistically significant MP changes were detected at one year. However, 10% of the cohort lost oRS ≥ 2 dB, and 73% lost ≥2 dB PWS in ≥5 loci, whereas 1% lost oRS ≥ 7 dB, and 4% lost ≥7 dB PWS in ≥5 loci. The foveola and temporal parafovea were the most vulnerable to severe RS loss. Compared to their counterpart, eyes with baseline oRS ≥ 25 dB had significantly more RS loss in the macula and superior parafovea (55% versus 32% and 53% versus 28%, both p = 0.01). Conclusions: Rather than oRS loss, ≥2 dB loss in PWS in ≥5 loci is a more feasible outcome measure for clinical trials in DMI.

Assistance Burden Comparison Between Age-Related Macular Degeneration and Retinal Angiomatous Proliferation Over a Three-Year Follow-up.

We compared assistance burden between neovascular age-related macular degeneration (nAMD) and retinal angiomatous proliferation (RAP) under intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment on a treat-and-extend (T&E) regimen in a third-level hospital in a developed country. This retrospective study using data from the Fight Retinal Blindness! Registry included patients treated between January 2016 and December 2020. Final event was established as best corrected visual acuity (BCVA) lower than 20 Early Treatment Diabetic Retinopathy Study letters. According to choroidal neovascularization (CNV), three different study groups were established: type 1, 2, and 3. A total of 285 eyes of 227 patients were included. Mean age was 80.1 ± 6.5, 79.1 ± 7.9, and 81.2 ± 7.2 years, for the three study groups, respectively. Mean injections were 16.0 ± 4.8, 16.5 ± 4.1, and 14.1 ± 5.7, respectively; and mean number of visits were 17.9 ± 4.3, 18.2 ± 3.1, and 16.8 ± 5.3, respectively. No differences were found (P > 0.05). Survival curves and log-rank analysis also showed no differences (P = 0.344). Cox proportional hazard models showed that a lower baseline BCVA, subfoveal geographic atrophy (GA), and subfoveal fibrosis (SF) were associated with a higher risk of reaching ≤ 20 letters. nAMD and RAP under a T&E regimen indicate a high assistance burden during the first three years. The presence of subfoveal GA or SF are associated with a BCVA lower than 20 letters. [Ophthalmic Surg Lasers Imaging Retina 2024;55:XX-XX.].

Effectiveness of Flash Card Media To Improve Early Childhood English Letter and Vocabulary Recognition in Reading

This research aims to analyze the effectiveness of Flash Card media to improve early childhood Alphabet and Spelling Vocabulary recognition in reading English at PAUD ADIAN Jaya Karang Sari. This study used qualitative method. The participants in this study were all students of “Class A” PAUD ADIAN Jaya Karang Sari. The result of  study on Effectiveness of Flash Card Media to improve the early childhood English Letter and vocabulary recognition in reading English show the implementation of Flash Card. The researcher showed some vocabulary in front of the student by the Flash Card. First, the researcher showed some picture in Flash card, then the researcher mention some vocabulary spell it in the flash card in English. Data was collected by interview and observation sheet. In interview, the researcher invited all the students to mention some vocabulary and student spell it in front of the class. In observation, the researcher makes some quiz about the vocabulary. The researcher showed the flash card. Then make a score for the students that can answer the words and spell it. This research give the implication how to important media learning for early childhood to study English.

Networks as interpretative frameworks: using co-citation analysis to explore large corpora of early modern letters

Abstract The analysis of co-citations, which occurs when two publications or authors are mentioned together in the same text, has long been established as a practice within scientometrics, particularly in the field of “science mapping”. However, historiography has shown less openness to utilizing co-citation analysis for distant reading purposes. To address this gap, this article presents a comprehensive methodology for applying co-citation analysis to extensive collections of historical documents, specifically 17th-century letters indexed in the ePistolarium database. In science mapping, co-citation serves as an indicator for tracking the development of scientific fields. Similarly, I employ co-citation to map the Dutch socio-intellectual landscape during the Scientific Revolution period (1623–87) and evaluate the strengths and limitations of this approach.

Privacy, Literacy, and Gender in Early Modern Jewish Letters from Prague (1619)

How private were Jewish letters in the early modern period? This article discusses Jewish epistolary culture and notions of privacy by examining an extraordinary cache of Jewish letters that were mostly written on a single day— 22 November 1619—in a single city, Prague, and sent to a single destination, Vienna. The letters never arrived and ended up in the archives where they were preserved for posterity. These letters allow us a glimpse into the lives of ordinary Jews in politically tumultuous times in which privacy and confidentiality could never be taken for granted. This article pays particular attention to gendered communication and privacy. It has been argued that in epistolary culture women are afforded a voice and speak for themselves. The evidence suggests that collaborative forms of writing that involved more than one writer were still common in early seventeenth-century Jewish correspondence, indicating zones of “privileged confidentiality” within larger family networks.

Efficacy and Safety of Brolucizumab for Diabetic Macular Edema

Despite the effectiveness of existing anti-vascular endothelial growth factor (VEGF) therapies, a need remains for further treatment options to improve response rates and/or reduce injection or monitoring frequency in patients with diabetic macular edema (DME). To evaluate the efficacy and safety of brolucizumab vs aflibercept dosed every 4 weeks in participants with DME. This 52-week, double-masked, phase 3 randomized clinical trial included treatment-naive adults and adults who had previously received anti-VEGF therapy. Data were collected from September 2019 to March 2020, and data were analyzed from April 2020 to February 2021. Brolucizumab, 6 mg, intravitreal injection every 4 weeks or aflibercept, 2 mg, intravitreal injection every 4 weeks. Participants were randomized 2:1 to brolucizumab, 6 mg, or aflibercept, 2 mg. The primary end point was change from baseline in best-corrected visual acuity at week 52. Secondary end points were the proportion of participants with a 2-step improvement or greater from baseline in Diabetic Retinopathy Severity Scale score, the proportion of eyes with absence of both subretinal fluid and intraretinal fluid, change from baseline in central subfield thickness, and safety at week 52. A total of 517 participants were randomized to brolucizumab (n = 346) or aflibercept (n = 171); 299 (57.8%) were male, and the mean (SD) age was 60.7 (10.2) years. Brolucizumab was noninferior to aflibercept in best-corrected visual acuity (Early Treatment Diabetic Retinopathy Study letter score) change from baseline at week 52 (brolucizumab, 12.2-letter improvement; aflibercept, 11.0-letter improvement; difference, 1.1; 95% CI, -0.6 to 2.9; noninferiority margin, 4; P < .001). Brolucizumab was superior to aflibercept for the proportion of eyes without subretinal and intraretinal fluid (brolucizumab, 144 of 346 [41.6%]; aflibercept, 38 of 171 [22.2%]; difference, 20.0%; 95% CI, 12.5to 28.6; P < .001) and mean central subfield thickness change from baseline at week 52 (brolucizumab, -237.8 μm; aflibercept, -196.5 μm; difference, -41.4; 95% CI, -58.9 to -23.8; P < .001). Incidence of intraocular inflammation was 4.0% (14 of 346) in the brolucizumab arm and 2.9% (5 of 171) in the aflibercept arm, incidence of retinal vasculitis was 0.9% (3 of 346) and 0.6% (1 of 171), respectively, and incidence of retinal vascular occlusion was 0.3% (1 of 346) and 0.6% (1 of 171). One participant in the brolucizumab arm had retinal artery occlusion. In these study participants with DME, no clinically meaningful differences in visual outcomes were noted between the brolucizumab and aflibercept arms; some superior anatomic improvements were noted in the brolucizumab arm. No new safety concerns were identified. ClinicalTrials.gov Identifier: NCT03917472.

62 The Print Knowledge as a Predictor of Reading Acquisition in Mexican Preschoolers

Objective:Print Knowledge in children starts with recognizing and characterizing printed figures; it is a precursor of other skills like letter knowledge and phonological awareness. The goal was to assess print knowledge components and their predictive value in emerging literacy in a sample of Mexican preschoolers.Participants and Methods:60 children (aged 4 to 6 years old; 50% boys and 50% girls) were tested with an analysis of the visual synthesis and the figure copy from the SNBP-MX and the Rey Complex Figure Test (children’s version).Results:Children with lower performance in the SNBP-MX cannot use visual information to perform correctly at the Rey Complex Figure. They have problems in the reproduction of the figure, and they do not respect the components of the Print Knowledge: 1) figure building characteristics (size, rotation, orientation) and function (relationship with the background and with other figures).Conclusions:Early visual perception skills impairments are related to the execution of elements from the Print Knowledge. Therefore, it is expected that children with low performance at visoperception and spatial tasks will have difficulties with early literacy. Since visual information is needed for the copy and learning of writing figures, print knowledge could be categorized as a predictor of the early word and letter recognition skills. We thank project PAPIIT IN308219 for sponsoring this research.

Ivor Timmis: The discourse of desperation: late 18th and early 19th century letters by Paupers, Prisoners, and Rogues

Ivor Timmis: <i>The discourse of desperation: late 18th and early 19th century letters by Paupers, Prisoners, and Rogues</i>

The long history of shortening: a diachronic analysis of abbreviation practices from the fifteenth to the twenty-first century

This article investigates continuities and changes in abbreviation practices from late Middle English to twenty-first-century digital platforms. Adopting a diachronic perspective and lexicological framework, it quantitatively analyses frequency patterns across fifteenth-century memoranda, letters and administrative receipts, seventeenth-century letters and depositions, late nineteenth-century letters, early twentieth-century letters and a subcorpus of WhatsApp instant messages dating from 2018–19. It then presents analyses of the frequencies of various abbreviation forms, such as clippings, and abbreviated lexemes, such as their use for names, over time. The article then provides a qualitative analysis of these lexeme categories over the centuries, with a focus on specific examples. Major changes to overall abbreviation density across time are identified. The forms of abbreviation also go through major change, but the types of lexemes that are abbreviated stay more consistent over time. For example, abbreviations being used for closed-class function words such as the and that are dominant from the earliest data we have looked at to the present day. Overall, the study demonstrates how situating new media abbreviation practices within a historical continuum can enhance our understanding of them.

Clinical Correlation of Retinal Fluid Fluctuation Represented by Fluctuation Index in Wet Age-Related Macular Degeneration: TOWER Study Report 2.

To explore outcomes and biomarkers associated with retinal fluid instability represented by a new parameter in neovascular age-related macular degeneration (nAMD). Patients with treatment-naïve nAMD receiving anti-vascular endothelial growth factor (VEGF) injections for a duration of 1 to 3 years were consecutively reviewed. Fluctuation Index (FI) of each eye, calculated by averaging the sum of differences in 1-mm central subfield thickness between each follow-up from months 3 to 24, was arranged into ascending order from the lowest to the highest and split equally into low, moderate, and high fluctuation groups. Outcomes were analyzed at 24 months. Of 558 eyes, FI values showed a negative correlation with a degree-response gradient with 24-month visual improvement. After controlling for baseline best-corrected visual acuity and potential confounders, eyes with low fluctuation gained more Early Treatment Diabetic Retinopathy Study letters than those in the moderate and high fluctuation group (Δ, 10.1 and 14.0 letters, respectively). Significant best-corrected visual acuity improvement from baseline to month 24 (11.8 letters) was observed exclusively in the low fluctuation group despite the indifference in the number of injections and types of anti-VEGF drug used among groups. Patients presenting with central subfield thickness of ≥405 µm or intraretinal fluid coinciding with subretinal fluid showed a significant association with foveal thickness instability during the maintenance phase. Apart from the central subfield thickness values, unstable macular thickening represented by the FI was associated with some baseline features and may contribute to substandard visual outcomes. FI may be a valuable tool for assessing therapeutic adequacy in the treatment of nAMD.

Editing the Letters of Mary, Queen of Scots: The Challenges of Authorship

ABSTRACTThis article addresses the challenges of attributing authorship to Mary, Queen of Scots, when editing her letters. It demonstrates how editing Mary’s letters offers evidence for reading early modern letters not as static texts but as evidence of the processes of early modern epistolary composition (namely, the collaborative nature of letter-writing in the period) and within a historicised understanding of authorship. An analysis of a range of Mary’s letters, from those written in her own hand, through to contemporary decipherment of coded letters, is offered to highlight the editorial challenges of her surviving correspondence. Close study of epistolary features such as signatures, script and handwriting, as well as an interrogation of the material features of Mary’s letters, suggests the benefits of a more practical approach to future editing of the correspondence.

Comparative assessment of subretinal hyper-reflective material in patients treated with brolucizumab versus aflibercept in HAWK and HARRIER

PurposePost hoc analysis of the phase III HAWK and HARRIER studies to compare the reductions in subretinal hyper-reflective material (SHRM) thickness following brolucizumab 6 mg or aflibercept 2 mg treatment...

Effectiveness of Flash Card Media To Improve Early Childhood English Letter and Vocabulary Recognition in Reading

This research aims to analyze the effectiveness of Flash Card media to improve early childhood Alphabet and Spelling Vocabulary recognition in reading English at PAUD ADIAN Jaya Karang Sari. This study used qualitative method. The participants in this study were all students of “Class A” PAUD ADIAN Jaya Karang Sari. The result of study on Effectiveness of Flash Card Media to improve the early childhood English Letter and vocabulary recognition in reading English show the implementation of Flash Card. The researchershowed some vocabulary in front of the student by the Flash Card. First, the researcher showed some picture in Flash card, then the researcher mention some vocabulary spell it in the flash card in English. Data was collected by interview and observation sheet. In interview, the researcher invited all the students to mention some vocabulary and student spell it in front of the class. In observation, the researcher makes some quiz about the vocabulary. The researcher showed the flash card. Then make a score for the students that can answer the words and spell it. This research give the implication how to important media learning for early childhood to study English.

The role of letter knowledge acquisition ability on children's decoding and word identification: Evidence from an artificial orthography

BackgroundLetter knowledge is crucial in the first stages of reading development. It supports learning letter‐sound mappings and the identification of the letters that make up words. Previous studies have investigated the longitudinal impact of early letter knowledge on children's further word reading abilities. This study employed an artificial orthography learning paradigm to explore whether the rate of letter learning modulates children's reading and word identification skills.MethodsIn an initial training phase, 8‐year‐old Spanish children (N = 30) learned nine artificial letters and their corresponding sounds (two vowels and six consonants). The letter learning rate was set according to the number of attempts needed to name at least seven letters (i.e., 80% correct). These ranged from 1 to 4. In a second training phase, children visualized words made up of the trained letters while listening to their pronunciations. Some words included a context‐dependent syllable (i.e., leading to grapheme‐to‐phoneme inconsistency), and others had an inconsistent syllable (i.e., phoneme‐to‐grapheme inconsistency). The post‐test consisted of a reading aloud task and an orthographic‐choice task in which the target word was presented with a distractor equal to the target except for the substitution of a letter.ResultsChildren showed a high accuracy rate in the post‐test tasks, regardless of whether words contained context‐dependent or inconsistent syllables. Critically, the letter learning rate predicted both reading aloud and identification accuracy of words in the artificial orthography.ConclusionsWe provide evidence for the vital role of letter knowledge acquisition ability in children's decoding and word identification skills. Training children on this ability facilitates serial letter‐sound mapping and word identification skills. Artificial orthography paradigms are optimal for exploring children's potential to achieve specific literacy skills.

Toward Practical 128-Bit General Purpose Microarchitectures

Intel introduced 5-level paging mode to support 57-bit virtual address space in 2017. This, coupled to paradigms where backup storage can be accessed through load and store instructions (e.g., non volatile memories), lets us envision a future in which a 64-bit address space has become insufficient. In that event, the straightforward solution would be to adopt a flat 128-bit address space. In this early stage letter, we conduct high-level experiments that lead us to suggest a possible general-purpose processor micro-architecture providing 128-bit support with limited hardware cost.

LONG-TERM PROGNOSIS OF CHOROIDAL NEOVASCULARIZATION COMPLICATING ANGIOID STREAKS.

To report the very long-term visual prognosis of choroidal neovascularization complicating angioid streaks in the antivascular endothelial growth factor era. Retrospective monocentric study aimed at analyzing patients' demographics, choroidal neovascularization features, angioid streak-associated conditions, and previous and current therapies for choroidal neovascularization. The main outcome measures were the quantitative measurement of central retinal pigment epithelial atrophy enlargement by comparing the ratio of pixels involved on automated infrared images acquired by spectral-domain optical coherence tomography and the changes in best-corrected visual acuity. The secondary outcome measures were the number of intravitreal injections and the changes in central choroidal thickness and central retinal thickness. Subgroup analyzes were performed to compare macular atrophy extent between eyes of patients with or without proven pseudoxanthoma elasticum ("PXE" or "no PXE") and between eyes previously treated or not with photodynamic therapy ("PDT" or "no PDT"). Thirty-three eyes of 23 patients were included. The mean best-corrected visual acuity decreased significantly from 66 ± 19 Early Treatment Diabetic Retinopathy Study letters at the time of the first antivascular endothelial growth factor injection to 52 ± 23 Early Treatment Diabetic Retinopathy Study letters at the end of the follow-up (mean follow-up duration: 109 ± 42 months, range: 47-175 months). The ratio of central retinal pigment epithelial atrophy enlargement was 201%, 110%, 240%, and 111% in the PXE, no PXE, PDT, and no PDT groups, respectively. Despite the use of antivascular endothelial growth factor agents, the very long-term prognosis appeared relatively poor, especially in patients with PXE. This study also suggests that PDT should be used with caution in the management of choroidal neovascularization in eyes with angioid streaks.

A real-world study for timely assessing the diabetic macular edema refractory to intravitreal anti-VEGF treatment.

Early Identifying and characterizing patients with diabetic macular edema (DME) is essential for individualized treatment and outcome optimization. This study aimed to timely investigate optical coherence tomography (OCT) biomarkers of DME refractory to intravitreal anti-vascular endothelial growth factor (VEGF) therapy. We retrospective reviewed 72 eyes from 44 treatment-naïve patients who were treated with intravitreal anti-VEGF for DME. OCT scans prior to anti-VEGF were evaluated for serous retinal detachment (SRD), size of outer nuclear layer cystoid changes, diffuse retinal thickening, integrity of the inner segment-outer segment (IS-OS) junction, quantity and location of hyperreflective foci, vitreomacular interface abnormalities, and epiretinal membrane (ERM). The Baseline best-corrected visual acuity (BCVA) and central macular thickness was recorded at baseline and 4 months after treatment with anti-VEGF. The main outcome measure was the correlation between spectral-domain OCT measurements and BCVA response at baseline and after anti-VEGF treatment (mean change from baseline; ≥ 10 Early Treatment Diabetic Retinopathy Study letters in BCVA). Partially continuous IS-OS layers (partially vs. completely continuous: β, -0.138; Wald chi-square, 16.392; P<0.001) was predictor of better response to anti-VEGF treatment. In contrast, ERM (present vs. absent ERM: β, 0.215; Wald chi-square, 5.921; P=0.015) and vitreomacular traction (vitreomacular traction vs. posterior vitreous detachment: β=0.259; Wald chi-square=5.938; P=0.015) were the predictors of poor response. The improvement of BCVA trended toward the OCT predictive value of central macular thickness reduction; however, this was not significant. Partially continuous IS-OS layers is predictive of better response to anti-VEGF therapy in DME. Meanwhile, ERM is a significant predictor of poor response.

Retinal vascular structure independently predicts the initial treatment response in neovascular age-related macular degeneration.

Prediction of the early treatment response is important in neovascular age-related macular degeneration (nAMD). Hence, we aimed to test if non-invasive measurements of the retinal vascular structure were able to predict a successful outcome of initial intravitreal treatment. In 58 eyes of 58 patients with treatment-naïve nAMD, advanced markers of retinal vascular structure were measured by Singapore I Vessel Assessment prior to initial intravitreal treatment with three monthly injections of aflibercept with subsequently categorization of patients as full treatment responders (FTR) or non/partial treatment responders (N/PR), with the former defined as loosing fewer than five Early Treatment Diabetic Retinopathy Study letters and having no residual intra- or subretinal fluid or macular haemorrhage. Of 54 eyes attending follow-up, 44.4% were categorized as FTR. Patients with FTR were older (81.5 vs. 77 years, p = 0.04), and prior to treatment those eyes had a lower retinal arteriolar fractal dimension (Fd) (1.21 vs. 1.24 units, p = 0.02) and venular length-diameter ratio (LDR) (7.3 vs. 15.9 units, p = 0.006), but did not differ with respect to other retinal vascular parameters. In multiple logistic regression models, a lower chance of FTR was independently predicted by a higher retinal venular LDR (odds ratio [OR] 0.91, 95% CI 0.82-0.99, p = 0.03, for each 1 unit increment) and marginally by a higher retinal arteriolar Fd (OR 0.83, 95% CI 0.68-1.00, p = 0.05, for each 0.01 unit increment). Retinal venular LDR independently predicted the initial treatment response in nAMD. If confirmed by long-term, prospective studies, this might help to guide treatment.

Special Issue of INFORMS Journal on Computing—Quantum Computing and Operations Research

Free AccessAboutSectionsView PDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinked InEmail Go to SectionFree Access HomeINFORMS Journal on ComputingAhead of Print Special Issue of INFORMS Journal on Computing—Quantum Computing and Operations ResearchCarleton Coffrin, Elisabeth Lobe, Giacomo Nannicini, Ojas ParekhCarleton Coffrin, Elisabeth Lobe, Giacomo Nannicini, Ojas ParekhPublished Online:15 May 2023https://doi.org/10.1287/ijoc.2023.cfp.v35.n3IntroductionQuantum computers offer an alternative way to approach computational problems, and it is widely believed that they can solve certain tasks significantly faster or with greater accuracy than any classical (i.e., nonquantum) computer. The impact of quantum computers on operations research, and vice versa, has thus far been limited, but this is expected to change. Indeed, the construction of more refined and scalable quantum hardware and software calls for the solution of a diverse range of problems that operations researchers are in prime position to address; examples include hardware design, hardware control, compiling, scheduling, and classical simulation of quantum devices. Furthermore, because of tremendous progress in hardware development and in the construction of basic algorithmic primitives, the last few years have shown significant growth in the volume of research dedicated to the application of quantum computers for the solution of operations research problems. This includes, but is not limited to, optimization, simulation, and learning.Special Issue ScopeThe INFORMS Journal of Computing wishes to promote high-quality research at the intersection of quantum computing and operations research. To foster the growth of the community and give visibility to top-tier work in this area, the Journal is devoting a special issue to this topic, and it invites authors to submit manuscripts that substantially advance the state of the art in methodology, theory, algorithms, applications, or software implementation as they pertain to all areas at the intersection of quantum computing and operations research. This includes, but is not limited to, novel results regarding the development and analysis of quantum or quantum-inspired classical algorithms for solving problems in operations research or based on the application of operations research techniques, the development of solution methodologies for problems that arise in the design and operation of quantum computers, and insightful empirical testing of the aforementioned types of algorithms.The main goal of this special issue is to give a platform to novel research in this emerging area. Survey and tutorial papers are included in this call; however, any survey or tutorial paper will have to maintain a very high standard of novelty and contribution with respect to existing surveys and tutorials in the open literature. We strongly encourage interested authors to contact one of the guest editors for this issue to discuss whether their work fits the scope of this special issue (see Timeline).The editorial statement of the journal is available at https://pubsonline.informs.org/page/ijoc/editorial-statement.Submissions should follow the standard requirements of the INFORMS Journal on Computing articles available at https://pubsonline.informs.org/page/ijoc/submission-guidelines.Please note that the INFORMS Journal on Computing has a data policy https://pubsonline.informs.org/page/ijoc/datapolicy and a software policy https://pubsonline.informs.org/page/ijoc/softwarepolicy.TimelineThe editors ask potential authors to prepare a short proposal, that is, a letter of intent, before making a full submission of a paper. Please note the following dates:September 30, 2023: Letter of interest sent to the editors (via email), with an abstract for the proposed contribution. (This step is not mandatory but strongly preferred to ensure proper review. Early letters are encouraged; submit the letter copying all guest editors).January 15, 2024: Deadline for first round of submissions.April 15, 2024: First round of reviews completed; decisions (and requests for revision, if appropriate) delivered to authors.June 15, 2024: Revisions due after first round decisions.August 15, 2024: Second round of reviews delivered to authors.August 30, 2024: Final versions of accepted papers must be submitted.Submission InstructionsPapers must be submitted online at https://mc.manuscriptcentral.com/ijoc.When submitting a paper, please note the following:Under “Step 1: Type, Title, & Abstract,”- select “Special Issue” for “Type,”- select “Special Issue” under “Select topic area of submission,”- and answer “Quantum Computing” for “If this paper is for a special issue, which one is it for?”. Back to Top Next FiguresReferencesRelatedInformation Articles In Advance Article Information Metrics Information Published Online:May 15, 2023 Copyright © 2023, INFORMSCite asCarleton Coffrin, Elisabeth Lobe, Giacomo Nannicini, Ojas Parekh (2023) Special Issue of INFORMS Journal on Computing—Quantum Computing and Operations Research. INFORMS Journal on Computing 0(0). https://doi.org/10.1287/ijoc.2023.cfp.v35.n3 PDF download